Journal of Clinical & Experimental Nephrology

Role of Calcium, Phosphorus and Intact Parathyroid Hormone in Different Stages of Chronic Kidney Disease

Background: Chronic Kidney Disease (CKD) normally hampered homeostasis of serum phosphorus calcium and intact Parathyroid Hormone (iPTH). Secondary Hyperparathyroidism (SHPT) arises in most patients during the progression of CKD, which is characterized by increased blood PTH levels. The aim of the study was to evaluate the role of calcium, phosphorus and iPTH levels in various stages of CKD.

Methods: Using a cross-sectional study design, we evaluated serum biochemical parameters and haemoglobin concentration among 70 CKD patients and 50 healthy persons as controls attending our outpatient nephrology clinic. CKD was defined as a glomerular filtration rate less than 60 ml/min/1.73 m² for 3 months or more, while anemia was defined as a Hemoglobin concentration (Hb) less than 11 g/dl.

Results: The mean age of the study participants was 52.5 ± 13.2 years and 40 (57.1%) of the patients were males. The most common causes of CKD were diabetic nephropathy (70%) and hypertension (30%). The mean serum calcium and mean iPTH were 8.01 ± 1.96 mg/dl and 139.92 ± 93.42 pg/ml respectively.

Conclusions: In our study statistically significant increase in the serum levels of intact parathyroid hormone, urea, creatinine, calcium and phosphorus in patients with CKD as compared with controls.

Author(s): S S Haque

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