Abstract
Molecular and Cellular Mechanisms of Systemic Autoimmune Diseases: Lessons Learned from Human Genetic Studies and Therapies in Systemic Lupus Erythematosus (SLE)
Systemic Lupus Erythematosus (SLE) is a prototypical systemic autoimmune disease characterized by a complex interplay of genetic, molecular and cellular factors. It is considered a multifactorial disorder influenced by genetic susceptibility, environmental triggers and dysregulated immune responses. Understanding the molecular and cellular mechanisms driving SLE pathogenesis has been instrumental in developing targeted therapies to manage the disease and improve patient outcomes. In this review, we will delve into the intricate molecular and cellular processes underlying SLE and examine the key lessons learned from human therapies.
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Journal of Clinical & Experimental Nephrology received 387 citations as per google scholar report
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