Journal of Clinical & Experimental Nephrology

Liver and Kidney Disease and Periodontal Disease : a Cross-sectional Study Based on Data from Oral Health Branch of Rafsanjan Cohort Study

Objectives: Several studies suggest that periodontal disease may be associated with some systemic disease, including liver and kidney disease. This research aimed to investigate the potential relationship between liver and kidney disease and periodontal disease. Methods: The study conducted a cross-sectional analysis on 8,682 individuals aged 35-70 who were registered with the Oral Health Branch of Rafsanjan Cohort Study (OHBRCS). OHBRCS is part of the Rafsanjan Cohort Study (RCS) and the larger Prospective Epidemiological Research Studies in IRAN (PERSIAN) initiative which began in 2015 in Rafsanjan, in southeastern Iran. After applying the inclusion and exclusion criteria, the final study population consisted of 6545 participants. To investigate liver disease, liver enzymes including Alanine Transaminase (ALT), Aspartate Transaminase (AST), Alkaline Phosphatase (ALP) and Gamma-Glutamyltransferase (GGT) were investigated. Hematuria and proteinuria and Glumerular Filtration (GFR) were used to check the kidney disease. In order to investigate periodontal disease,all subjects were examined by dental specialists in terms of gum health parameters, including bleeding during probing or BOP, gingival erosion or CAL, pocket depth of the probe or the presence of dental calculus. Univariate and multivariate logistic regression analyses were performed to analyze the data. Results: No significant association was found between liver and kidney disease indexes and periodontal disease indexes. Conclusion: Overall, this study suggests that there was no significant association between liver and kidney disease and periodontal disease.

Author(s): Dr. Frederick Sarfo-Antwi

Abstract | PDF

Share this