Journal of Clinical & Experimental Nephrology

Immunomodulatory and Anti-Inflammatory Therapeutic Potential of Mscs inDiabetic Nephropathy

Diabetic nephropathy (DN) is a microvascular complication of diabetes mellitus (DM) and the main reason for end-stage renal diseases (ESRD). Currently, inflammation has been recognized as one of the underlying processes involved in the development and progression of kidney disease in the diabetic population. mesenchymal stem cell (MSC) therapy has been considered a promising strategy to ameliorate the progression of DN. They are multipotent and have immunomodulatory effects to assist in the recovery from tissue injury and the inhibition of inflammation. This review discusses recent experimental and clinical findings related to diabetic kidney disease, with a focus on the immunomodulatory and anti-inflammatory role of MSCs.

Author(s):

Pardis Abolghasemi*1, Benyamin Khatamsaz

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