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Role of Circulating Serum Apelin-13 Levels in Glomerulonephritis: A Pilot Study

Introduction: Apelin is secreted from white fat tissue, and it is an adipokine. Increased apelin levels were observed in kidney biopsy of rats formed nephropathy throughout glomerular basal membrane. Thus, the purpose of this study was to evaluate the difference of apelin-13 levels in patients with  glomerulonephritis and healthy patients.

Materials and Methods: This study included 107 subjects, comprising 53 glomerulonephritis patients that were newly diagnosed and under continuing treatment and 54 healthy individual used as control group. Demographic data and laboratory findings were recorded from hospital information file system. Apelin-13 levels were compared between the patient and control group. Furthermore, relationship between apelin-13 levels and arterial blood pressure, mass body index, proteinuria, albumin, creatinine was evaluated in the patient group.

Results: Apelin-13 level exhibited averages of 1863 ± 1783 pg/ml in patient group and 2392 ± 1846 pg/ml in control group. No significant differences were found between groups. Apelin levels between the glomerulonephritis patients with proteinuria and glomerulonephritis patients without proteinuria were  compared, patients with proteinuria had 1784 ± 1756 pg/ml and patients without proteinuria had 2274 ± 1896 pg/ml apelin-13. Between the two groups there was not a significant difference.

Discussion: In summary, our findings indicate that apelin-13 levels showed no significant difference  between the patients with glomerulonephritis and healthy control group.


Yasemin Coskun Yavuz, Can Sevinc, Mustafa Saygin Deniz, Serkan Yavuz, Orcun Altunoren2, Ahmet Celik, Recep Demirci, Hayriye Sayarlioglu and Ekrem Dogan

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