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Abstract

Can Urinary Total Protein-to-Creatinine Ratio Determine the Presence of Micro albuminuria in Patients with eGFR> 60 ml/ml/min/m²?

Objective

To determine the relationship between spot urine total protein-to-creatinine ratio (TPCR) and albumin-to-creatinin ratio (ACR) in diabetic and/or hypertensive patients with estimated glomerular filtration rate (eGFR) greater than 60 ml/min/m2 and to determine the optimal TPCR value that can predict microalbuminuria.

Methods

190 diabetic and/or hypertensive patients who had eGFR ≥ 60 ml/min/1.73 m2 were studied. Urine dipstick test, spot urine TPCR and ACR values of the patients were evaluated.

Results

 A strong positive correlation was found between ACR and TPCR (p<0.001; r=0.565). The optimal cut-off value for TPCR was 119 mg/g. Sensitivity, specificity and AUC for this cut-off value were 83%, 69% and 0.811, respectively. According to the dipstick test, only 20.9% of the patients had microalbuminuria in the urine protein negative group.


Author(s):

Aysun Aybal Kutlugun, Fatma Ayerden Ebinc and Mujgan Tek



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Abstracted/Indexed in

  • China National Knowledge Infrastructure (CNKI)
  • Directory of Research Journal Indexing (DRJI)
  • WorldCat
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