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Can Urinary Total Protein-to-Creatinine Ratio Determine the Presence of Micro albuminuria in Patients with eGFR> 60 ml/ml/min/m²?


To determine the relationship between spot urine total protein-to-creatinine ratio (TPCR) and albumin-to-creatinin ratio (ACR) in diabetic and/or hypertensive patients with estimated glomerular filtration rate (eGFR) greater than 60 ml/min/m2 and to determine the optimal TPCR value that can predict microalbuminuria.


190 diabetic and/or hypertensive patients who had eGFR ≥ 60 ml/min/1.73 m2 were studied. Urine dipstick test, spot urine TPCR and ACR values of the patients were evaluated.


 A strong positive correlation was found between ACR and TPCR (p<0.001; r=0.565). The optimal cut-off value for TPCR was 119 mg/g. Sensitivity, specificity and AUC for this cut-off value were 83%, 69% and 0.811, respectively. According to the dipstick test, only 20.9% of the patients had microalbuminuria in the urine protein negative group.


Aysun Aybal Kutlugun, Fatma Ayerden Ebinc and Mujgan Tek

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