Reach Us +1-947-333-4405
All submissions of the EM system will be redirected to Online Manuscript Submission System. Authors are requested to submit articles directly to Online Manuscript Submission System of respective journal.


AQP-3 in the Epidermis of Haemodialysis Patients with CKD-Associated Pruritus is Overexpressed

Background: Xerosis is considered to be one of the causes of chronic kidney disease-associated pruritus (CKD-aP). In the present study, the relationship between CKD-aP and aquaporin-3 (AQP-3), the water channel in the skin was examined in light of xerosis.

Methods: AQP-3 expression in the epidermis and patients characteristics included stratum corneum hydration (SCHy) were compared in haemodialysis patients (HD-pts) without pruritus (n = 23), HD-pts with slight to mild pruritus (n = 12), and HD-pts with moderate to severe pruritus (n = 7).

Results: In HD-pts, there was association between CKD-aP and both range and intensity of epidermal AQP-3 expression. The range and intensity of AQP-3 expression in the skin was significantly greater in HD-pts with severe CKD-aP than in HD-pts without CKD-aP, as shown by anti- AQP-3 staining that was both more intense and extended to more superficial layers of the skin.

Conclusions: CKD-aP was shown to be associated with epidermal AQP-3 expression but not with xerosis, which was quantified in this study using SC-Hy. In addition, there was no association between xerosis and epidermal AQP-3 expression. These results indicate that xerosis, which has been considered to be a cause of CKD-aP, is not a necessary and sufficient condition for CKD-aP, and that the mechanism of the onset of xerosis may not involve epidermal AQP-3 in HD-pts.


Akishi Momose, Tomihisa Funyu, Ryuichi Wada and Yasuo Shiraiwa

Abstract | Full-Text | PDF

Share this  Facebook  Twitter  LinkedIn  Google+
Flyer image

Abstracted/Indexed in

  • China National Knowledge Infrastructure (CNKI)
  • Directory of Research Journal Indexing (DRJI)
  • WorldCat
  • Publons
  • Secret Search Engine Labs